[Objective] This study proposes a new convolutional neural network model, aiming to process the imbalanced data of online patient reviews. [Methods] First, we established the new model with mixed sampling and transfer learning techniques. Then we used end-to-end deep learning architecture based on Word2 Vector and convolutional neural network for the distributed representation, feature extraction and topic classification of online patient reviews. [Results] Compared with traditional machine learning algorithm represented by SVM and single convolutional neural network, the proposed model significantly improved the accuracy, recall and F1 values.[Limitations] The imbalanced data of this study was only from online patient reviews. [Conclusions] The proposed model could effectively improve the recognition results of imbalanced data.