Margaret Sanger (1879-1960), a famous international birth control movement leader, devoted herself to the movement from 1910 to 1960 approximately. This article aims to investigate: the story why Margaret Sanger became a birth controller; what she had done to promote the birth control movement during the earlier period (1912-1916). Since 1873 federal Comstock laws made contraception advice and devices illegal, many women didn't know how to avoid pregnancy and had no choice but access to abortion against unwanted pregnancies. In 1910, Margaret Sanger joined a visiting nurse association, and she nursed in the tenement of New York's Lower East Side, where Margaret Sanger saw many working-class women died after a botched abortion. Because of that, she came to understand what those women really needed; information about effective contraception. Therefore, in 1912, Margaret Sanger resolved to leave nursing and began to advocate the need of birth control as a tool by which working-class women would liberate themselves from the economic burden of unwanted pregnancy. Initially, she began writing a column on sex education for the New York Call entitled “What Every Girl Should Know” in 1912, In 1914, she published the Woman Rebel, a radical feminist monthly, and was indicted for violating laws. Unwilling to risk a length imprisonment, Margaret Sanger set sail to European.