This article aims at providing a preliminary analysis of the legal definition of religion in the First Amendment to the Constitution of the United States. As the Supreme Court, the court of the highest jurisdiction in the United States, is the only authority that interprets the Constitution, the task of this essay is twofold: a study of the religion clause in the First Amendment, and an analysis of the Supreme Court’s interpretation of the religion clause. By reviewing some selected cases, this article argues that the Supreme Court’s explication of the legal definition of religion in the First Amendment has gradually moved from an exclusivistic approach to an inclusivistic approach that embraces various kinds of religion that are heterogeneous to the traditional monotheistic Judeo-Christian religion.