The purpose of this study was to explore the effects of acupressure on stroke patients suffering from constipation. Acupressure refers to massage therapy focused on the acupoints of Chinese medicine; the points used in this study were ST-25 (tian shu), SP-15 (da heng), CV-6 (qi hai), CV-4 (guan yuan), ST-36 (zu san li), and ST-37 (shang ju xu). The research was designed as a clinical trial utilizing a total cohort of 60 inpatients suffering from stroke; the patients were selected in accordance with the criteria established by the research of our rehabilitation hospital. These patients were then divided into two groups of 30 patients each for the trial. In the experimental group, the research investigator instructed the patients?caretakers in standardized point location and massage techniques, while patients in the control group were given the traditional standard nursing care. Prior to the experiment, the demographics and potential causative factors of constipation within the two groups were compared to establish that all had a similar baseline (p> .05). Following acupressure, the experimental group showed a marked improvement versus the control group in the frequency of: passage of flatulence (p= .000), the desire to defecate (p= .000), easing of abdominal distention (p= .000), smooth defecation (p= .000), and overall bowel movements (p= .000). The results of our research may be applied in clinical nursing care to improve the quality of care while reducing the need for medication and reducing the total cost of treatment.