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題名：補充靈芝對衰竭運動後老鼠抗氧化能力及肌肉損傷之影響
書刊名：大專體育學刊
作者：康如佩／劉介仲／林俊宏 引用關係／張惟翔 引用關係／謝錦城 引用關係
作者(外文)：Kang, Ju-pei／Liu, Chieh-chung／Lin, Chun-hong／Chang, Wei-hsiang／Hsieh, City C.
出版日期：2010
卷期：12:2
頁次：頁95-101
主題關鍵詞：肌酸激酶；乳酸去氫酶；丙二醛；過氧化物歧化酶；穀胱甘肽過氧化酶；Creatine kinase；Lactate dehydrogenase；Superoxide dismutase；Glutathione peroxidase；Malondialdehyde
原始連結：連回原系統網址new window
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  • 被引用次數被引用次數:期刊(3) 博士論文(0) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:3
  • 共同引用共同引用:9
  • 點閱點閱:110
本研究旨在探討補充靈芝對衰竭運動後老鼠體內抗氧化能力及肌肉損傷之影響。以40隻雄性老鼠為研究對象，隨機分成控制組、衰竭運動組、靈芝組和靈芝運動組，共四組，各10隻。補給靈芝的組別每天以每公斤體重40mg/kg劑量餵食老鼠，為期四週；運動組於最後一週進行跑步機適應，隔天以漸增式衰竭運動跑至衰竭。採二因子變異數分析來考驗靈芝補充與衰竭運動對老鼠血液中肌酸激酶、乳酸去氫酶、丙二醛、過氧化物歧化酶、榖胱甘肽過氧化酶活性之影響。結果發現衰竭運動組的肌酸激酶、乳酸去氫酶、丙二醛活性顯著高於控制組，過氧化物歧化酶及榖胱甘肽過氧化酶活性則顯著低於控制組(p<.05)。且靈芝運動組乳酸去氫酶、丙二醛活性皆顯著低於衰竭運動組(p<.05)，過氧化物歧化酶活性則顯著高於衰竭運動組(p<.05)，肌酸激酶與榖胱甘肽過氧化酶則無顯著差異(p>.05)。由上述總結，補給靈芝能有效防止衰竭運動導致過氧化物歧化酶活性之降低及乳酸去氫酶與丙二醛活性升高之情形，有助於增強老鼠體內之抗氧化能力，減緩因衰竭運動導致氧化傷害及肌肉損傷之情形。
This study was designed to investigate the effects of Ganoderma lucidum supplementation on antioxidant status and muscular damage after exhaustive exercise in rat. Forty male Sprague-Dawley rats were randomly divided into four groups: control (C, n=10), exhaustive exercise (E, n=10), Ganoderma lucidum treated (G, n=10) and Ganoderma lucidum plus exhaustive exercise (GE, n=10). Ganoderma lucidum was supplemented at the dose of 40 mg/kg body weight for four weeks. Exhaustive exercise was performed on a rodent treadmill with the progressive protocol. Two way ANOVA was carried out to examine the effects of exhaustive exercise and Ganoderma lucidum supplementation on creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels. The activities of CK, LDH and the levels of MDA in E group were significantly (p<.05) higher than C group, while the activities of SOD and GPx were significantly (p<.05) lower than C group. However, LDH activity and MDA level were significantly lower in GE group compared to E group, and SOD activity was significantly increased with Ganoderma treatment compared to E group. Results from our study demonstrate that Ganoderma lucidum supplementation is beneficial to increase antioxidant status, and reduce the elevation of oxidative stress and muscular damage in exhaustive exercised rats.
期刊論文
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2.Johnson, P.(2002)。Antioxidant enzyme expression in health and disease: Effects of exercise and hypertension。Comparative Biochemistry and Physiology，133，493-505。  new window
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10.林學宜(1998)。七公里路跑對五專男生肌肉及肝功能之影響。宜蘭農工學報，16 期，209-215頁。  延伸查詢new window
11.Avula, C. P. R.、Fernandes, G.(1999)。Modulation of antioxidant enzymes and lipid peroxidation in salivary gland and other tissues in mice by moderate treadmill exercise。Aging (Milano)，11(4)，246-252。  new window
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15.Lakshmi, B., Ajith, T. A., Jose, N.,、Janardhanan, K. K.(2006)。Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene。Journal of Ethnopharmacology，107，297-303。  new window
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會議論文
1.謝錦城、許壬榮、呂學冠、廖威彰、劉燦榮(1998)。衰竭運動對老鼠紅血球脂質過氧化物、變形性形態學的影響17-28 頁。  延伸查詢new window
學位論文
1.吳德玉(2004)。規律運動訓練對心血管疾病危險群婦女危險因子及情緒狀態之影響(碩士論文)。臺北醫學大學。  延伸查詢new window
2.朱嘉華(1999)。國小教師身體活動與睡眠品質之相關研究(碩士論文)。國立臺灣師範大學，台北市。  延伸查詢new window
3.李淑玲(2002)。補充含抗氧化劑之碳水化合物飲料對耐力運動期及恢復期生理與生化值之影響(碩士論文)。國立體育學院。  延伸查詢new window
4.詹芷琪(2007)。松杉靈芝之補充對大鼠之運動表現及力竭運動後抗氧化狀態之影響(碩士論文)。臺北醫學大學。  延伸查詢new window
5.傅惠鈺(2004)。靈芝延緩衰老之研究，臺中市。  延伸查詢new window
 
 
 
 
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