This report was about using hospice care in terminal oral cancer patient's care, the nursing care period was from 3rd March 2014 to 18th 2014, the methodology I used was hospice philosophy to evaluate patient's reaction from physiological, psychological, social and spiritual aspects, we also applied actual interactive process with physical assessment, observation, companionship, listening, and empathy to carried out overall assessment. After analysis and summary, I established ineffective breathing patterns, chronic pain, and anticipatory grief health problems. Due to compression of the respiratory tract caused dyspnea and choke, the patient with head and neck cancer always felt panic and fear, and their families were also totally lost. It was the motivation for me to write this report; I recommend that patient instructions should add timely tips related symptoms and care; according to the individual needs to establish care plan as early as possible to reduce anxiety of patient and their families. During the nursing care, nurse observed cases of respiratory, pain, vital signs and pre-dying signs, By case situation and needs, at any time to discuss with the physician, Drug adjustment routine nursing care and care of the whole attitude is to make the case comfortable hospice core, except dealing with drugs, With the condition, is consciousness clear, attention is also being led to be transferred, and the willingness to cooperate, I led patient into relaxation breathing training and imagination therapy, I also used lavender essential oil to carry out aromatherapy; those measures could temporary remission the ineffective breathing patterns and chronic pain. Medical care team members conducted patients and their families about four steps in the end of life; they encouraged patients to send a message in a bottle to her daughter to express her love; and this action could make up her regret for unable to accompany the growth of her daughter. I hoped that through the discussion in this article, it could provide medical care team members some care knowledge and ability to promote patient’s quality of life; and help patient to have a serene and calm end well, at same time, also assist the family member could be more comfortably with well good- by and well carefree when facing the death of patient.