As aging, the prevalence of Alzheimer's disease and cognition dysfunction increase in many countries. Studies showed that the Apolipoprotein Epsilon4 (Apo ε4 ) allele is a significant genetic risk factor for Alzheimer's disease (AD). The Apolipoprotein ε (Apo ε) gene is localized on chromosome 19 in a single locus with three alleles (ε2, ε3, and ε4) responsible for the three major Apo ε isoforms (Apo ε2, Apo ε3, and Apo ε4). The Apo ε4genotype results to morphological change of brain tissue and lead to reduction of cerebral oxygenation, impairment of cognition, and hippocampi volume atrophy. Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain. The M170 peak in MEG was identified as a potential marker for pre-clinical decline as ε4 carriers exhibited longer M170 latency, and lower M170 amplitude than healthy adults. This literature review showed that: 1. The cognitive function was impaired due to the low cerebral blood flow and oxygenation in middle and old age Apo ε4 carriers. 2. Middle and old age Apo ε4 carriers are often associated with higher degree of hippocampus atrophy. 3. The increase of physical activity level can shorten M170 latency, increase M170 amplitude and result to improvement of brain executive control function in Apo ε4 carriers.