Quality of Life and Social Function in Patients with Schizophrenia or with Bipolar Disorder Receiving Long-acting Antipsychotics_

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題名：	Quality of Life and Social Function in Patients with Schizophrenia or with Bipolar Disorder Receiving Long-acting Antipsychotics
書刊名：	Taiwanese Journal of Psychiatry
作者：	陳文瑩／林式穀
作者(外文)：	Chen, Wen-yin／Lin, Shih-ku
出版日期：	2017
卷期：	31:4
頁次：	頁309-317+a7
主題關鍵詞：	生活品質；社會功能；住院；長效針劑；Quality of life；Social function；Hospitalization；Depot medication
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:1 點閱:6

目的：思覺失調症和雙相情緒障礙症病人在藥物依從性不佳時，長效注射抗精神病劑（LAIs）提供了一個潛在的解決方案。在本研究中，我們比較接受LAI 治療的思覺失調症及雙相情緒障礙症病人的主觀經驗和臨床特徵。方法：總共449 例思覺失調症病人和45 例雙相情緒障礙症病人定期接受LAI 治療至少6 個月，施予簡短版世界衛生組織生活品質 (WHOQOL) 問卷，抗精神病劑治療下之主觀幸福感量表，個人與社會功能量表、臨床嚴重度整體評估表和病識感缺乏量表。所有病人進行病歷回顧，確定其病程中的住院頻率。結果：LAI 治療的思覺失調症病人 (p < 0.05) 和雙相情緒障礙症病人 (p < 0.05) 的住院次數（次／年）皆明顯下降。兩組病人的WHOQOL 的總體評分和四個領域得分均低於台灣均數。雙相情緒障礙症病人的WHOQOL 總體得分及社交領域得分明顯較高於思覺失調症病人 (p < 0.05)。結論：LAI 治療可有效減少藥物依從性不佳的病人之精神病症狀或情緒發作的住院次數。在LAI 治療下，病人可以維持一定的生活質量水平和社會功能。研究結果建議使用LAI 治療於口服藥物依從性不佳的精神病病人。

以文找文

Objective: Long-acting injectable antipsychotics (LAIs) provide a potential solution to overcome poor adherence to oral medications in patients with schizophrenia and bipolar disorder. In this study, we compared variables of subjective experiences and clinical features of patients receiving LAI treatment with schizophrenia and bipolar disorder. Methods: Totally, 449 patients with schizophrenia and 45 patients with bipolar disorder who were regularly on LAI treatment for at least 6 months received the brief version of the World Health Organization Quality of Life (WHOQOL) questionnaire, Subjective Well-being under Neuroleptics scale, Personal and Social Performance scale, Clinical Global Impression of Severity scale, and lack of insight scale. We conducted a retrospective chart review in all patients to determinate the frequency of hospitalizations during their illness course. Results: The frequency of hospitalizations (times/year) was decreased significantly after LAI treatment in patients with schizophrenia (from 0.26 ± 0.42 to 0.12 ± 0.45, p ＜ 0.05) and bipolar disorder (from 0.53 ± 0.65 to 0.16 ± 0.40, p ＜ 0.05). The overall WHOQOL scores and the scores of the four domains were lower than the Taiwanese norm in both groups. Patients with bipolar disorder had significantly higher social domain score than did patients with schizophrenia (p ＜ 0.05). Conclusions: LAI treatment can efficaciously prevent the relapse of patients with schizophrenia or bipolar disorder with poor adherence to medications. Under LAI treatment, patient can keep a certain level of QOL and social function. We recommend LAI treatment as an extensive regiment in patients with poor adherence to oral medications.

以文找文

期刊論文
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