Many factors influence OHCA (Out-of-Hospital Cardiac Arrest) patient survival outcome, including patient baseline conditions, early recognition, early access, early bystander CPR (cardiac pulmonary resuscitation), EMT (emergency medical technician) first-responding intervention and time, early defibrillation, capability of receiving hospital, and post-arrest care, etc. Based on the OHCA data-sets administrated by Kaohsiung City Fire Bureau in 2017, This research was a retrospective cohort study. By methodologies of literature review, independent sample T-test, chi-square test, and logistic regression analysis toward relevant cases via SPSS 20.0 software, these OHCA data-sets were classified into four aspects, including "patient demography", "dispatch mode (number of EMTs) and treatment", "AED (automated external defibrillator) defibrillation or not", and "each administrative time", so as to find out the factors most successful relevant to the OHCA survival. The factors significantly relevant to ROSC (return of spontaneous circulation) outcome in hospital, includes "responding time", "total case time", "EMT-Paramedic medication intervention", "AED defibrillation". Therefore, in order to improve the OHCA survival rate, it is worthy for the authorities to take a reference and focus on, how to shorten responding time as well as total case time, and how to enhance early AED defibrillation as well as EMT-paramedic medication intervention on the OHCA patient.