This case report describes the critical care of a 29-year-old patient with CO intoxication-related lung injury after a house fire accident. The period of nursing was May 29 to June 20, 2016. The skills used included conversation, evaluation, observation, and Roy's adaptation-model implementation. The patient's health problems included impaired gas exchange, sleep pattern disturbance, and anxiety. During the nursing process, the nurse built a relationship with the patient and his family, helped them to process weaning endotracheal tube failure, and provided them with psychological support to assist the patient and his family to adapt and return to normal family life and society. The author's experience may help peers who are nursing patients with CO intoxication undergoing critical nursing care.