Objectives: The purpose of this study was to examine the effectiveness of intelligent process management design in the cross-unit handover (CUH) system. Methods: First, an original cross-unit handover (CUH) process was systematically reviewed. Subsequently, cross-platform tools were developed using Apache Cordova. Next, consensus on the standardized and structured format of handover from a patient preparation (delivery site) department to an execution department was obtained. Subsequently, data were automatically transformed to this system from systems such as a structured physician ordering system, nursing information system, and laboratory information system. After system execution by the clinical unit, data regarding the outcome were collected. Results: Implementing the intelligent process management design engendered the following: (1) It improved work efficiency by reducing personnel cost and saving working hours (383.4 h/month). (2) It increased the turnover rate of the operating room from 97.5% to 103.4%. (3) Moreover, it reduced overtime pay (TWD$ 300,000 /per year). (4) Finally, it reduced printing material cost (TWD$ 40,000 /per year). Conclusions: The study results demonstrate the effectiveness of the innovative design in enhancing patient safety.