Objectives: This research investigated the relationship among communication channels regarding betel-nut information, characteristics of the recipient, and betel-nut chewing knowledge, attitude and behavior. Method: A structured questionnaire was used to interview subjects in Taiwan from October, 1995 to February, 1996. Altogether, 1652 adults consisted the sample. Results: (1)The most frequently mentioned channels of betel-nut information were television, journals and relatives/friends. (2)Younger adults, who had a higher education, students or middle-class adults received betel-nut information from magazines, newsletters, brochures, posters, lectures and schooling. Aborigines, eastern Taiwan residents, and those who lived in mountainous areas frequently received betel-nut information from interpersonal channels (i.e., relatives/friends and health professionals ). (3)Those who had received betel-nut information from television, magazines, and health professionals, tended to have higher scores in knowledge about betel-nut chewing. (4)Those who had received information from television, and health professionals, tended to have stronger attitude against the use of betel-nuts. (5)Those who had received betel-nut information in school were less likely to chew betel-nuts. Conclusions: According to these findings, it is recommended that betel-nut information be focused on people who are rarely exposed to the relative information. The right channels should be used to approach the recipients. Communication channels s uch as television, magazines, schooling, and health professionals should be used more frequently to disseminate information related to the harmfulness of betel-nut chewing.