應激對興奮性突觸傳遞的影響及其分子機制__臺灣人文及社會科學引文索引資料庫

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題名：	應激對興奮性突觸傳遞的影響及其分子機制
書刊名：	心理科學進展
作者：	李每易／王春蓮／王子卿／陳煥新
出版日期：	2017
卷期：	2017(12)
頁次：	2021-2029
主題關鍵詞：	應激；皮質激素及受體；內側前額葉皮層；興奮性突觸傳遞；AMPA和NMDA受體；Stress；Glucocorticoid and receptors；Medial prefrontal cortex；Excitatory synaptic transmission；AMPA and NMDA receptors
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:8

應激與抑郁癥、心血管疾病及腫瘤等重大疾病的發生有著密切關系。前額葉皮層和海馬是調控應激反應的重要組織,也是應激作用的靶器官。興奮性突觸傳遞是大腦功能活動的重要基礎,應激通過改變遞質的釋放和代謝及受體的轉運和表達,影響突觸傳遞功能。包括表觀遺傳在內的多種細胞內信號通路參與了應激的作用機制。揭示這些信號通路可為研發治療應激相關疾病的藥物提供潛在的靶點。

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Stress is strongly associated with depression, cardiovascular disorders and cancers. The prefrontal cortex and hippocampus are not only important regions regulating the stress response, but also the main targets of stress. Excitatory synaptic transmission plays an essential role in the brain function, which is affected by stress through altering the transmitter release and metabolism,and the expression and trafficking of postsynaptic receptors. Multiple intracellular molecular signal cascades are involved in the underlying mechanisms of the stress response. Thus, understanding these mechanisms may provide potential targets for discovering the novel therapeutic treatments of stress-associated disorders. 更多

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圖書論文
1.	Lang, T.、Jahn, R.(2008)。Core proteins of the secretory machinery。Handbook of Experimental Pharmacology。Springer。

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