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題名:一種建構細胞治療產業關鍵成功因子的創新方法
作者:邱淳芬
作者(外文):CHIU, CHUAN-FENG
校院名稱:中華大學
系所名稱:科技管理博士學位學程
指導教授:裴文
學位類別:博士
出版日期:2022
主題關鍵詞:細胞治療產業層級分析法決策實驗室分析法關鍵成功因子創新策略管理Cell therapy industryAnalytic Hierarchy Process (AHP)Decision Making Trial and Evaluation Laboratory (DEMATEL)key success factorinnovative strategic management
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再生醫學的領域中,細胞治療被視為非常重要的項目,臨床上常被應用於器官或
組織的再生修復,可以廣泛應用於多種疾病治療上,被視為具潛力之新興療法。近幾
年,台灣政府已將生物科技產業列為核心戰略產業項目,在其中,更是為了細胞治療
產業設立專法列管,導致細胞治療產業產生了重大變化,使細胞治療公司有法規可依
循並進行發展,藉此推動了許多細胞治療公司。因此,本篇研究主要以細胞治療產業
為研究主題,採用文獻探討與實地訪談細胞治療專家學者建立研究架構,其中包含相
對重要的三個評選層面 (dimensions) 與十四個關鍵成功因子 (key success factors),結
合層級分析法 (AHP) 與決策實驗室分析法 (DEMATEL) 方法設計問卷,問卷發放與
回收後進行分析,評選出細胞治療公司治理關鍵層面與因素之修先次序與因果關係。
本研究以台灣指標性的細胞治療公司,國璽幹細胞應用技術股份有限公司為案例對象
進行研究探討。本研究期望透過研究分析結果提供國內細胞治療公司可靠的策略建議。
研究結果顯示,三層面優先次序以技術層面 (TC) 最重要,此外,經過台灣細胞治療
產業的劇烈變化,十四個關鍵成功因子的優先次序以技術層面 (TC) 下的產品開發策
略 (TC1) 與技術掌握能力 (TC2) 為最重要之關鍵成功因子,此外,因果關係方面,
技術層面下之產品開發策略 (TC1) 與技術掌握能力 (TC2) 亦為最值得細胞治療公
司關注與改善的關鍵成功因子。
In the field of regenerative medicine, cell therapy is often used to regenerate organ or
tissue that can be widely applied to several diseases. In recent years, the Taiwanese
government has listed the biotechnology industry as a key development objective, and has
enacted laws to regulate cell therapy. This has led to substantial change and has necessitated
a reliable direction of management in the cell therapy industry. Therefore, this study aims to
develop a new method to explore the key success factors (KSFs) in three dimensions of
relevant biotechnology company management. It adopts a qualitative method combined with
a quantitative analysis method. The study uses Gwo Xi Stem Cell Company, a qualified cell
therapy company in Taiwan, as a case study. It adopts a literature analysis method and
conducts interviews with cell therapy industry experts to develop an innovative assessment
framework. The analytic hierarchy process (AHP) is combined with Decision Making Trial
and Evaluation Laboratory (DEMATEL) to establish the KSFs in the management of the
cell therapy industry. Thus, the study offers strategic recommendations for the development
of domestic stem-cell-related industries. The results demonstrate technical characteristics
(TCs) as the most important direction for successful management. Moreover, due to the
substantial change in Taiwan’s cell therapy industry, TC-related KSFs, including product
development strategy (TC1) and technological mastery (TC2), are currently considered to
be crucial KSFs in decision making.
Aaker, D. A. (1989). Managing assets and skills. The key to a sustainable competitive advantage. Calif Manage Rev, 31(2): 91–106. DOI:10.2307/41166561.
Amsden, A. H. & Mourshed, M. (1997). Scientific publications, patents and technological capabilities in late-industrializing countries. Technol Anal Strateg Manag; 9(3): 343–360. DOI:10.1080/09537329708524289.
Alliance for Regenerative Medicine (ARM), Available Products, accessed on 1 June 2021. https://alliancerm.org/available-products/.
Alliance for Regenerative Medicine (ARM). (2022). Regenerative Medicine: Disrupting the Status Quo. https://alliancerm.org/sector-report/2021-annual-report/.
Arojärvi, O. (2001). How to Value Biotechnology Firms: A Study of Current Approaches and Key Value Drivers. MS thesis, Aalto University, http://urn.fi/URN:NBN:fi:aalto-2020111714729.
Aslami, M. J. (2019). The effect of project management on organizational performance – the case of NGOs in Afghanistan. MBA Thesis, Istanbul Aydin University, DOI:10.2139/ssrn.3395721.
Barney, J. B. (1986). Organizational culture: Can it be a source of sustained competitive advantage? AMR; 11(3): 656–665. DOI:10.2307/258317.
Becker, G. S. (1964). Human capital: A theoretical and empirical analysis, with special reference to education. NBER. http://www.nber.org/chapters/c14407.
Bogue, D. J. (1969). Principles of Demography. New York: Wiley.
Chen, L. Y. (2017). Yearbook of Applied Biotechnology Industry. Taipei, DCB. 2017.
Chang, C. W.,Wu, C. R. & Lin, C. T. (2006). An application of AHP and sensitivity analysis for selecting the best slicing machine. Comput Ind Eng 2007; 52(2): 296–307. DOI:10.1016/j.cie.
Chang, P. L. & Chen, Y. C. (1994). A fuzzy multi-criteria decision making method for technology transfer strategy selection in biotechnology. Fuzzy Sets Syst; 63(2): 131–139. DOI:10.1016/0165-0114(94)90344-1.
Chen, Y. C., Cheng, H. F. & Yeh, M. K. (2017). Cell therapy regulation in Taiwan. Cell Transplant; 26(3): 483–492. DOI:10.3727/096368916X693293.
Chesnais, F. (1988). Technical cooperation agreements between firms. STI Review; 4(0): 51–120.
Crawford, L. (2006). Developing organizational project management capability: Theory and practice. Proj Manag J; 37(3): 74–86. DOI:10.1177/875697280603700308.
Dahlman C and Westphal L. The meaning of technological mastery in relation to transfer of technology. Ann Am Acad Political Soc Sci 1981; 458: 12–26. http://www.jstor.org/stable/1044311.
Edvinsson L and Sullivan P. Developing a model for managing intellectual capital. Eur Manag J 1996; 14(4): 356–364. DOI:10.1016/0263-2373(96)00022-9.
Ernst H. Patent information for strategic technology management. World Pat Inf 2003; 25(3): 233–242. DOI:10.1016/S0172-2190(03)00077-2.
Evans JS. Strategic flexibility for high technology manoeuvres: A conceptual framework. J Manag Stud 1991; 28(1) :69–89. DOI:10.1111/j.1467-6486.1991.tb00271.x.
Farrell B, Kenyon S and Shakur H. Managing clinical trials. Trials 2010; 11: 78. DOI:10.1186/1745-6215-11-78.
Fishman M and Porter J. A new grammar for drug discovery. Nature 2005; 437: 491–493. DOI:10.1038/437491a.
Fujiwara T. Real options analysis on strategic partnerships of biotechnological start-ups. Technol Anal Strateg Manag 2014; 26(6): 617–638. DOI: 10.1080/09537325.2014.923834.
Gabus A and Fontela E. The DEMATEL Observe. Geneva, Switzerland: Battelle Geneva Research Center. 1976.
Gabus A and Fontela E. World problems, an invitation to further thought within the framework of DEMATEL. Geneva, Switzerland: Battelle Geneva Research Center. 1972:1–8.
Grant RM. Toward a knowledge-based theory of the firm. Strat Mgmt J 1996; 17(S2): 109–122. DOI:10.1002/smj.4250171110.
Hofer CW and Schendel D. Strategy formulation: analytical concepts. Minnesota, West Publ., 1980.
Industrial Developmental Bureau, Ministry of Economic Affairs, Taiwan (R.O.C.). (2022). 2021 Taiwan Biotechnology Industry White Paper.
IQVIA. (2021). Global Medicine Spending and Usage Trends: Outlook to 2025. https://www.iqvia.com/insights/the-iqvia-institute/reports/global-medicine-spending-and-usage-trends-outlook-to-2025.
IQVIA. (2021). The Global Use of Medicines 2022: Outlook to 2026. https://www.iqvia.com/insights/the-iqvia-institute/reports/the-global-use-of-medicines-2022.
IQVIA. (2022). Biosimilars to Continue Rapid Growth Over the Next Decade. https://www.iqvia.com/blogs/2021/12/biosimilars-to-continue-rapid-growth-over-the-next-decade.
Khalil TM. Management of technology: The key to competitiveness and wealth creation. Boston: McGraw-Hill. 2000.
Konstantinov I. E. In search of Alexander A. Maximow: the man behind the unitarian theory of hematopoiesis. Perspectives in biology and medicine 2000; 43(2); 269–276. https://doi.org/10.1353/pbm.2000.0006.
Laínez JM, Schaefer E and Reklaitis GV. Challenges and opportunities in enterprise-wide optimization in the pharmaceutical industry. Comput Chem Eng 2012; 47: 19–28. DOI: 10.1016/j.compchemeng.2012.07.002.
Levitt S and Snyder J. Political parties and the distribution of federal outlays. AJPS 1995; 39(4): 958–980. DOI:10.2307/2111665.
Luo SW. A Study of Successful and Failure Path for New Product Development. MS Thesis, Feng Chia University, 2010. https://hdl.handle.net/11296/32xmu5.
McCulloch E. A., Till J. E., Siminovitch L. The distribution of colony-forming cells among spleen colonies. Journal of cellular and comparative physiology 1963; 62; 327–336. https://doi.org/10.1002/jcp.1030620313.
Murdick RG. Business policy: a framework for analysis. Ohio, Grid Pub., 1980.
Niosi J and Bas TG. The competencies of regions – Canada's clusters in biotechnology. Small Bus Econ 2001; 17: 31–42. DOI:10.1023/A:1011114220694.
Porter ME. Competitive strategy: techniques for analyzing industries and competitors. New York: Free Press, 1980.
Porter ME. The Competitive Advantage of Nations. New York: Free Press. 1990.
Rautiainen T. Critical Success Factors in Biopharmaceutical Business: Finland vs. California. MS thesis, 2000.
Saaty TL and Vargas L. Decision making with the analytic network process. International Series in Operations Research & Management Science 2006; 95: 1–26. DOI:10.1007/0-387-33987-6.
Saaty TL. Decision making – the analytic hierarchy and network processes (AHP/ANP). J Syst Sci Syst Eng 2004; 13(1): 1–35. DOI:10.1007/s11518-006-0151-5.
Saaty TL. The analytic hierarchy process: planning, priority setting, resource allocation. New York: McGraw-Hill International Book Co., 1980.
Song, Jy., Kang, H.J., Ju, H.M. et al. Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses. Sci Rep 2019; 9; 6623. https://doi.org/10.1038/s41598-019-42964-7.
Sullivan P. Focus groups confirm that MDs, public differ on role of private health care. CMAJ 1996; 154(8): 1247–1249.
Taiwan Research-based Biopharmaceutical Manufacturers Association (TRPMA). Overview of R&D of Taiwan’s regenerative medicine industries (in Chinese). Taipei, TRPMA, 2020.
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5); 861–872. https://doi.org/10.1016/j.cell.2007.11.019.
Takeuchi H and Nonaka I. The new product development game. Harv Bus Rev 1986; 64(1): 137–146.
Tamura H and Akazawa K. Structural modeling and systems analysis of uneasy factors for realizing safe, secure and reliable society. J Telecom Inf Technol 2005; nr 3: 64–72.
Tarek M. Khalil. Management of Technology: The Key to Competitiveness and Wealth Creation. New York: McGraw Hill. 2000.
Teece DJ. Firm organization, industrial structure, and technological innovation. J Econ Behav Organ 1996; 31(2): 193–224.
Thomas E. D. Bone marrow transplantation: a review. Seminars in hematology 1999; 36(4 Suppl 7); 95–103.
Till, J. E., & McCulloch, E. A. A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells. Radiation Research 1961; 14(2); 213–222. https://doi.org/10.2307/3570892.
Tsai TH, Ling TY and Lee CH. Adoption of regulations for cell therapy development: Linkage between Taiwan and Japan. Clin Transl Sci 2020; 13(6): 1045–1047. DOI:10.1111/cts.12813.
Tushman ML and Rosenkopf L. Organizational determinants of technological change: Towards a sociology of technological evolution. Res Organ Behav 1992; 14: 311–347.
Van Norman GA. Drugs, devices, and the FDA: part 1: an overview of approval processes for drugs. JACC: Basic to translational science 2016; 1(3): 170–179. DOI:10.1016/j.jacbts.2016.03.002.
Wernerfelt B. A resource-based view of the firm. Strat Mgmt J 1984; 5(2): 171–180. Retrieved August 26 2021, from www.jstor.org/stable/2486175.
Wood EH, Tang PH, De la Huerta I, et al. Stem cell therapies, gene-based therapies, optogenetics, and retinal prosthetics: current state and implications for the future. Retina 2019; 39(5): 820–835. DOI:10.1097/IAE.0000000000002449.
Zheng XD. The beneficial analysis of Taiwan's biotechnology industry. Journal of Bank of Tawian 2014; 60(3); 71-95. https://www.bot.com.tw/SiteCollectionDocuments/resource_103/quarterly_103/60_3/quarterly60_3_5.pdf

 
 
 
 
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