The purpose of this case study was to examine the physical-psychological responses for one primary caregiver of an AIDS infected parent hospitalized at a hospital in northern city of Taiwan. Interviews and observations of the caregiver occurred between June 4, 2000 and June 23, 2000. Eight process recordings were completed. The main physical responses of the caregiver were sleep pattern changes and poor appetite. The psychological responses were fear of being infected by AIDS, fear of discrimination by society, being asking about his parent's illness, or isolation from social activities. Watson's Theory was used to establish a positive interpersonal relationship and trust with the caregiver, to provide information about medical resources, and to guide appropriate care of the caregiver, including giving hope and sharing feelings with him. In conclusion, the caregiver showed improvement in several areas: agreeing to have an AIDS screening test at prevention center, change in sleep pattern to normal, and actively discussion with his uncle and aunt about his parent's illness.