Many student of American social history have stressed the importance of the backgrounds in the immigrants’ adjustment to American life. The adaptation of Italian and Chinese offers an illuminating case study of the differential role in American urban setting between 1865 and 1965. It goes without saying that, in addition to the family, there were other institutions, such as the district organization, which also facilitated the newcomers’ adjustment. This article is focused mainly on the adaptation of the immigrant family and social background, which had its unique characteristic in addition to some similar roles played by all these institutions. After all, it was because of their strong family ties that the Italian were frequently referred to as the “Chinese of Europe.” In many ways, the Italian and Chinese experiences looked similar. It was during the same decade the 1880s, for example, that the two immigrant groups arrived in America in large numbers although they came to the city for different reasons: Italians made New York their first choice in migrating to the United States due to the abundant employment opportunities offered in the city while the Chinese moved here in an effort to avoid the anti-Chinese movement in California. By 1890s, several Little Italys and Chinatowns ahd become a salient feature of the city’s life. Furthermore, both groups had largely agrarian backgrounds. However, the question of whether the two immigrant groups’ familism had the same quality and played the same role in their adjustment has not received sufficient attention. By comparing the lives of Italian and Chinese immigrants, this article aims to explore these questions, and discuss the complicating roles played by discrimination and ethnic heritage in shaping the experiences of the two immigrant groups.