Establishment of a museum paradigm deals heavily with expectation and experience of target visitors. Expectation is based on experience, a vital index for sustainable operation and development of any museum. Development and establishment of concerned theories or tools for defining and describing museum experience become essential topics in museum research. Knowledge is the subject of a museum exhibit. The essence of education lies on effective knowledge dissemination. Museum experience can therefore be defined as “a knowledge dissemination process through exhibit communication.” A knowledge dissemination process in museum environment consiss of five major steps: recognition behavior, message selection, information structuring, experience internalization, and knowledge formation. Based on which, a set of basic framework for museum experience illustration, or exhibit information analysis, is proposed, which has four elements, namely, thematic orientation, descriptive method, content structuring approach, and knowledge core. This framework can be employed to analyze not only museum experience of exhibits on various levels but also evolutionary patterns of modern museums and of exhibition experiences, and to suggest directions for new museum paradigms and novel exhibition categories.