The study of this article is to introduce the concept of an innovative business model in “Uranium Enterprise”, which is alike to the gigantic energy brought from the chain reaction of the chemical element uranium 235. The scale of such enterprise is small with few employees, unlike the large company in labor-intensive or capital-intensive industry needing more labors and capital investment, but Uranium enterprise can still reach out placing significant influence on global market and stand at a pivotal position to affect the development of some industry. Uranium enterprise applies the disruptive technology or business model of innovation, rather than those from large enterprises, to “turn stone into gold by merely touching it” and let the very small company itself earn utmost profit. Even further, such enterprise contributes significantly to its related industry as a pivot in a whole value chain, and helps peer members upstream and downstream of the industry making profits and sharing values, resulting in a multi-lateral winning situation. The pivoting Uranium enterprise owns niche intellectual properties and assets, such as brand name or technical know-how with the function of catalyst, therefore to trigger the chain reaction just like the key role of a match vs. a barrel of gasoline or a trigger vs. a pistol/gun.