Objectives: Physicians willingness is the main factor determining the approval of prescription refills for chronic diseases. The aim of the current study was to investigate the factors influencing the willingness of clinic physicians to approve prescription refills. Methods: Of 8, 830 clinic physicians in the National Health Insurance database, 4,000 physicians were randomly surveyed with structured questionnaires. Of the 4,000 questionnaires mailed to the physicians, 813 were returned. Descriptive and multiple regression analyses were performed to identify those factors determining clinic physicians' willingness to approve prescription refills. Results: Of the physician respondents, 50.5% were willing, or very willing, to approve prescription refills for chronic diseases, whereas 32.7% of clinic physicians were unwilling, or very unwilling, to do so. The three major reasons determining a physician's unwillingness to approve prescription refills were: 1) concerns related to medical malpractice, 2) inconvenience associated with the process, and 3) the possibility of the prescription being changed. One-half of physicians were not satisfied with the policy pertaining to the approval of prescription refills. After controlling for other factors, the factors significantly associated with the physicians' willingness to approve prescription refills included: 1) empathy for the patient's medical condition, 2) increased medication problems, 3) the pharmacist's competence in safely dispensing medications, 4) establishing a separate global budget payment schedule for prescription refills, 5) satisfaction with the reimbursement for prescription refills, 5) hiring the pharmacist, 6) years of practice, 7) weekly patient volume, and 8) a physician’s speciality. Conclusions: One-half of the clinic physicians sampled in the current study were willing to approve prescription refills for chronic diseases. By focusing on the factors associated with the physicians' unwillingness to approve prescription refills and working to overcome them, the rate of approving prescription refills may be increased.