Abstract The main purpose of this research is to investigate the feasibility of γ-ray irradiation for the disinfection of molded paper-based artifacts. The following results can be obtained:3 KGy of γ-ray irradiation are sufficient biocidal dosage to the fungi strains. There are not apparent brightness and color change for the filter papers after 3 KGy of γ-ray irradiation, whereas the decrease in breaking length and folding endurance of papers occurred gradually. γ-ray irradiation applied for treating molded paper artifacts may induce damage potentially, and it must be used carefully. In addition further tests would be needed.