Patentability, as one of the fundamental elements of the patent system, is essential in the patent law. Patentability determines not only if a patent should be granted or not, but also a patent's validity when an infringement claim is brought up. Among the benchmarks for determining the patentability, non-obviousness is considered the most intriguing and uncertain issue. The decision of the US Supreme Court in KSR Infernational Co. v. Teleflex Inc. ("KSR".), which concerns non-obviousness, is said to be the landmark case in US patent law over the past few years. This case revisited the principles developed in Graham v. John Deere Co. of Kansas City, and the so-called Teaching, Suggestion, and Motivation (TSM) rules. In the following essay, I will first pursue what TSM rules connote, and what issues the application of TSM rules ahs created in the legal practice. Then I will look into the KSR and the connections between TSM rules and the KSR. Finally, I will try to explain the indications of the KSR, and its impacts on the legal practice.