Some researches showed that pictures could increase the interest of contents, attract readers' attention, and help them understand the words. Most of the researches focused much more on the roles, backgrounds, styles and so on, than on the relationship between the layout of pictures and words and readers' comprehension. Therefore, we tried to apply Kress and Leeuwen's view, the structure of Given and New, in our study. In this structure of Given and New, Kress and Leeuwen analyzed the relation between two pictures on one page. They defined the picture on the left side representing the "Given" information which is known by people, whereas the picture on the right side means the "New" information which people want to know. However, they didn't indicate that the layout of the contents of the words could be imitated in this structure. Therefore, with the four present articles with two pictures and the contents, we applied the structure to replace the contents in four different style layouts. We expected to know, after readers read one article, whether the layout could affect their comprehension. The result showed that the readers' reading comprehension is better when the content was placed on the given part (the left side) and above the picture. It is hoped that the result could improve the layout and its researches in the future.