Abstract The traditional Taguchi method mainly aims at the optimization of a single quality characteristic. In fact, there are usually two or more quality characteristics contained in a product or a manufacturing process. In general, the engineer’s experiences are crucial to the determination of factor levels while dealing the issue of multiple quality characteristics. The uncertainty or ambiguity, however, happens frequently for the various standards from different engineers. In addition, when there are more quality characteristics considered or the quality characteristics are more relevant, it would be more difficult for the engineer either to decide the best combination of factor levels or to solve the problem of multiple quality characteristic conflicts. Consequently, determining the product optimization of multiple quality characteristics has become a very important issue in improving the enterprise product quality. The optimization of multiple quality characteristics in the product or manufacturing process is critical for promoting the product quality or the process capability. Therefore, the research first applied Taguchi method considering only one quality characteristic to separately calculate the S/N rations which were then transferred to the Grey Relational Coefficient by the Grey Relation Analysis. Next, the Fuzzy Inference System was utilized to find the Multiple Performance Characteristics Index (MPCI). The higher the values were, the better the parameter combination would be. After that, the main factors that simultaneously affected two quality characteristics were found by executing Analysis of Variance, which verified the best parameter combination for two or more quality characteristics. Finally, taking the TFT metal coating process in the LCD manufacture as an example, the present research explained the numerical analysis of the optimization procedure and pattern to demonstrate its effectiveness and practicality. It is hoped that this study will help the company save the cost for experiment and time for moving the stage from experiment to production.