本研究目的為評價化學治療護理知識庫導入後，比較兩組護理人員在化學治療知識的差異。本研究設計採類實驗法，研究對象依立意取樣，選取某醫學中心5個化學治療相關病房之護理人員，使用化學治療護理知識庫者為實驗組(n=38)及查詢傳統書面資料者為對照組(n=43)。研究工具含基本資料、化學治療知識問卷及化學治療護理知識庫接受度問卷，於化學治療護理知識庫實施前進行前測及實施後第三、四月進行第一、二次後測。研究結果以描述性統計、ANOVA、T test檢定、GEE model進行資料分析。結果顯示化學治療護理知識庫介入後，有效提升護理人員的專業知識，統計上呈顯著差異（Z(下標 組別*時間1)=5.41，p<.0001；Z(下標 組別*時間2)=3.77，p=.0002)且接受度達73%，期望本研究結果能供日後相關單位推廣及應用。

The purpose of this study is to evaluate the chemotherapy knowledge base for nurses. The research compares nurses' understanding and application of chemotherapy knowledge before and after the application of chemotherapy knowledge base. The nursing knowledge base system was based on information from reference studies, drug index of chemotherapy, and dosing instructions: which included information about drug effects, side effects, drug administration, and drug precautions. Sampling judgement was used to choose the subjects for study, and 81 nurses who worked in five chemotherapy wards in a medical center were divided into an experimental group (n=38) and a control group (n=43). The tools of research were demo- graphic questionnaires concerning chemotherapy knowledge and practice. All of the subjects were pretested, tested again after three months and then tested one final time after the fourth month. The data was analyzed by descriptive statistics, ANOVA, the T test, and the GEE model. The data results showed that after the chemo- therapy-knowledge base for nurses was applied, the scores of the experimental group increased noticeably (Z(subscript group*time1)=5.41, p<.0001; Z(subscript group*time2)=3.77, p=.002). The results also showed that the chemo- therapy-knowledge base for nurses did improve nurses' professional knowledge, earning it wider acceptance among nurses (73%). We hope the results are informative and useful for related organizations.