This article describes the nursing care provided to a patient admitted to intensive care unit who had Vibrio vulnificus infection and septic shock. The data was collected from April 8 to 18, 2009. Based on Gordon eleven functional health patterns, we established four major health care issues: changes in tissue perfusion, acute pain, impaired tissue integrity, and anxiety. During the nursing process, the team used therapeutic interpersonal relationship procedure to provide individualized physical and mental nursing interventions and addressed the acute physical needs of the patient. The team provided further knowledge about Vibrio vulnificus infection with necrotizing fasciitis and ways to improve wound self-care ability. The team also discussed with nutritionists to plan a nutrition therapy for the patient in order to enhance wound healing. We hope the nursing experience from this patient may be helpful for caring patients with similar conditions in the future.