輪班的工作對於護理人員的心理健康是有害的，根據調查發現輪班工作的護理人員憂鬱症的盛行率高達23%，而且輪班工作愈多年憂鬱症狀的盛行率也愈升高，這是造成護理人員流動率增加的原因之一。根據研究指出大夜班的護理人員血清中發炎因子的濃度較其他班別高，血清中發炎因子的濃度增加是造成憂鬱的重要因子，造成輪班工作的護理人員血清中有較高濃度的發炎因子與生理、精神壓力、睡眠、飲食、體重、運動等都有密切關係，發炎反應的增加會提高憂鬱症狀的發生，相反的，降低發炎反應則具有降低憂鬱症的作用，所以為了減少憂鬱纏身，可透過建立良好的生活習慣來降低發炎反應，進而預防憂鬱發生。

Shift work is harmful to the mental health of nurses. According to a survey, the prevalence of depression among shift work nurses is as high as 23%, which is one of the reasons for the increase in nursing staff turnover. Serum concentration of inflammatory factors is an important factor in causing depression. Physiological and mental stress, sleep, diet, weight and exercise are closely related to serum inflammatory factors in shift work nurses. The increased inflammatory response would increase the incidence of depressive symptoms. On the contrary, a reduced inflammatory response would reduce depression symptoms. Therefore, in order to reduce depression among shift work nurses, good habits can be established to reduce inflammation and to prevent depression.