Faced with increasingly more complex urban problems, we need to consider not only physical aspects, but also non-physical ones, in order to effectively manage these problems. The establishment of the city management discipline can be complementary to the traditional field of urban planning, covering both aspects. The present paper reviews, compares and analyzes the background and need of the establishment of the city management discipline in the US, Mainland China and Taiwan. From the viewpoint of discipline design and based on the logic of managing large, complex systems, we depict the framework and content of the city management discipline, including research issues, technologies, research orientations, theories and methodologies, etc. This research argues that the city management discipline should be improved through the following aspects: (1) Complexity science and decision science should be applied as the theoretical basis for city management in order to make rational decisions in the complex urban systems; (2) City management should define its research scope by answering four basic questions: How do cities work? How should cities work? How are plans and decisions made? And how should plans and decisions be made? (3) The basic methods and instruments for the research of city management may include decision analysis, policy analysis, planning analysis, city modeling and analysis, and planning support systems.