In recent years, the research and discussion of the literature of Republican Period of China has become much more active, and it has formed an academic space full of vibrancy and possibility. In the process of the interpretation and construction of the literature of Republican Period of China, the most fundamental problem that is unavoidable and must be solved is undoubtedly to define its temporal and spatial framework. Because Taiwan and China have different interpretation and insistence on the concept of time and territory of Republican Period of China, and it causes a confusion and distress of researching. Some viewpoints on this unavoidable problem are raised in this article. The rupture and continuity of historical facts exist in the temporal framework of Republican Period of China and the complex phenomena of separation and unity in the spatial framework of Republican Period of China are pointed out in this article. To solve this problem, the concept of "characteristics of Republican Period of China" is raised by the author. The characteristics are modern, democratic, civilian, and of China and so on. The "characteristics of Republican Period of China" are formed at the stage of the mainland period of republic of China, and continued at the stage of the Taiwan period of republic of China. Thus, the temporal and spatial framework of research on the literature of Republican Period of China are clarified and operated reasonably.