The research aimed to document and assess the development of a community-based integrated screening information system (CISIS) by a team consisting of community nurses and managers. A questionnaire survey was conducted among frontline employees (including those in the nursing department, administration and information office) to assess the prospect of the new system. Hands-on testing demonstrated significant advantages of the system. It provided patient identification label printing, streamlined registration and was compatible with other in-house systems. Results showed that registration processing time was considerably reduced (by 70 seconds per case). Patients also spent less time filling up forms manually (by 320 seconds per case). Scores of perceived usefulness were high among staff who came in first contact with the system. They expressed willingness to use the CISIS in future screening sessions despite a technical issue of connection stability due to limited internet coverage in some areas. We concluded that establishment of the CISIS was effective in strengthening primary health care and public health programs. In the next phase, in addition to the current edition, we plan to introduce wireless (or Bluetooth) data transmission and apps, incorporating smart devices and barcode scanner. This is expected to contribute to the making of a unique, comprehensive, customer-oriented healthcare facilities.