The linked exchange rate system requires that the interest rate in Macau must be consistent with that in Hong Kong, and then with that in the U.S. It implicates that, to some extent, monetary supply in Macau must be affected by U.S monetary policy. This paper examines how the change of monetary supply in Macau that caused by U.S monetary policy affects inflation under the linked exchange rate system. The result shows that monetary supply in Macau caused by U.S monetary policy has less effect on inflation in period of depression but has more effect on inflation in a period of economic boom. The finding presents a new explanation of inflation in Macau.