When analyzing the construction of a high-quality life circle between Macau and Zhuhai from the perspective of residential environment livability, similarities and differences can be seen between the two places in terms of nature, economy, humanities and social resources. Aunique natural environment, mutually beneficial tourist industry, cultural environment of the same origins and special social environment are all advantages of the construction of a high-quality life circle in the two places. The effects caused by Macau ’s reclamation include damage caused to the ecological environment, the differences of the economic development and structure between the two places, the decline of Zhuhai ’s creative spirits and the systems being unequal. These hinder their cooperation. In the long run, the two places should intensify cooperation in terms of natural environment, economic industry, college education and port channel.