The aim of this article is to describe the nursing care experience of a homeless patient with multiple skin ulcers and hypokalemia in the emergency department. The period of nursing care ran from June 30 through July 8, 2015. The patient was evaluated with Gordon's eleven health functions evaluation by direct nursing care, physical examination, observation, conversation, and listening skills. Four nursing problems were determined, including infection, pain, potentially self-harm, and poor adjustment ability. During the clinical nursing period, we established a good interpersonal relationship with the patient. We provided wet dressing for wound care and taught relaxation techniques to relieve his pain. We also offered a comfortable environment with cardiac monitor for observation. After that, we listened to the patient's experience and encouraged him to express his feelings in order to enhance patient's confidence for improved self- care ability. We also offered medical team services and social resources for continued care and to assist the patient to return to a healthy and normal life as soon as possible. Lastly, due to no social workers are available at night and on holidays, we recommend the hospital to consider the allocation of social workers in order to solve the problem of resettlement of homeless patients in a timely fashion for a more efficient use of emergency department resources.