Background & Problems: Lack of work environment design may cause improper posture in employees, and even lead to long term cumulative musculoskeletal injuries. From a survey in 2013, we found that within a day there were 15 nurses in the working environment of our unit having improper posture, with the accumulation of 1769 times, and an average of 117.9 times/person. We found that the main cause of improper posture included: lack of knowledge; lack of appropriate assistive devices; setting, size and height of equipment not meeting the needs of the workers; lack of overall environment planning, and lack of regular checklist monitoring. Purpose: The purpose of this project was to reduce the frequency of improper posture of nurses during work, thereby to increase job satisfaction. Resolution: Several interventions were included, such as staff in-service education and training, slogans posted, purchase of assistive devices, use of ergonomics concepts to redesign materials and equipment placement, and development of checklist monitoring etc. Results: After intervention, the frequency of improper posture of nurses in the working environment reduced from 1769 times to 488 times, with an average reduction of 117.9 times to 32.5 times/person. The overall job satisfaction in the working environment was improved from 50.7% to 87.5%. Conclusion: This project was effective in reducing the frequency of improper posture of nurses in the working environment, and improving the overall job satisfaction. Hopefully we may extend this project to related units, to create a high efficient work environment.