The report described the nursing experience of caring a 19-year-old girl with multiple open fractures on limbs due to a drunk-riding motorcycle accident. The patient received bilateral femoral open external reduction and Hoffman fixation on July 1, 2015. The patient and her families faced the unexpected accident, expressing extreme worry about the progression and prognosis of the injury. The nursing period was from July 4 to August 12, 2015. Using the 11 Gordon functional health assessments tool, data were collected by listening, interview, role participation, and physical examination. Three major health problems were identified, including acute pain, impaired physical mobility, and anxiety. Based on the identified health problems, the medical team provided necessary care, including education about the postoperative pain control method, assistance of physical activities placement, assistance of improving physical comfort, arrangement of doctors updating the disease progression, and provision of postoperative rehabilitation program. After discharge, the patient could perform daily activities independently. In addition, the patient returned to her favorite coffee bar working after a month. The health care team provided patients and her family memberswith the postoperative rehabilitation and discharge care plans to facilitate participation. At the same time, the patient and her family members followed the daily rehabilitation care schedule and adjusted the plan timely based on status of the patient. Before being discharged, the patient was assessed to ensure self-care ability after discharge. The results of this nursing experience provides a reference for caring patients with multiple fractures.