This paper described the experience of caring for a patient with terminal liver cancer and bone metastases who experienced physical pain and discomfort and loss of self-care ability. The care period was from March 16 to April 2, 2017, and data were collected using interviews, physical assessments, observations, and direct care. A comprehensive evaluation and data integration, analysis, and organization were performed using Gordon's 11 functional health patterns, establishing that the patient had pain, fluid volume excess, and sense of hopelessness. During the caring process, comfortable positioning, acupressure, and aromatherapy were used to relieve pain and discomfort. The patient was instructed in acupressure massage and in controlling a low-sodium diet with fluid restriction, as well as close monitoring of intake and output to mitigate the problem of fluid volume excess. Reminiscence therapy and family support were used to assist the patient with adapting to changes in the disease and strengthening mindfulness, affirming self-worth and reducing the sense of hopelessness caused by terminal cancer. Medical care providers are recommended to pay attention to the spiritual needs of patients with terminal cancer, and to assist them in adapting to the disease as well as attaining physical and mental comfort, thereby ensuring that the patients can receive appropriate care. This care experience is shared as a reference for use in clinical practice.