Biomedical knowledge is often considered difficult for adolescents. However, if we can apply the right tools
effectively in education, it would be easier to help expand adolescents’ scientific knowledge. In recent years, the
application of Merge Cube in Augmented Reality has gradually expanded to science education for adolescents.
Since Merge Cube is regularly used with a single-function app and is rarely story-driven, in our research, we
applied Merge Cube to a multifunctional app and emphasized more on the story elements. With the teaser
animation as the opening, the whole project is story-driven and designed in an integrated AR environment. The
digital content in the project includes five themes, which are 2D interaction, 3D animation, 3D games, the hall
of fame, and website, aiming to create an entertaining and educational innovative field while the adolescents
learn about biomedical knowledge. This research is an interdisciplinary project. The biomedical materials are
provided by The Department of Biological Science and Technology of I-Shou University. From these materials,
we use Merge Cube as the platform and Unity software as an integration tool to produce and design digital
content respectively throughout this large-scale project. All the digital content will then be integrated into a
mobile app in the end. Once the app is opened, users can hold the Merge Cube in front of their smartphones, and
enjoy the digital content. After the project is completed, we conducted four exhibitions respectively in Pingtung,
Chiayi, Kaohsiung, and Penghu in cooperation with the popular science dissemination activities held by the
Ministry of Science and Technology. According to our survey on the participating students in the exhibitions,
over 90 percent of students believed this project helped them understand more about biomedical knowledge and
considered the digital content intriguing. The results indicate that the project have received positive affirmation.