The prupose of this study was to investigate stress and coping in nurses confronting with patients' families. The subjects included 109 nurses who have been working at National Taiwan University Hospital for more than six months. Structured questionaires were used for data collection and advanced statistics including Factor analysis, t- Test, GLM ANOVA, and Canonical correlation were used in this study. The results revealed that the sources of nurses' stress from patients' families could be divided into 3 major categories: stress from families' lack of medical information, stress from families' care burdens of patients. Degree of stress was significantly different across nurses' age, education, hospital units where nurses works, and level of family nursing which had been done. The coping methods adopted by the nurses could be divided to active problem -solving, passive- thinking, and avoidance. Active problem- solving was the most commonly used coping methods. The graduates of junior college adopted avoidance more frequently than nurses with bachelor degree. In the canonical correlation analysis, one significant variate set differentiated nurses on stress. Nurses who experienced higher drgree of stress more often adopted passiv- thinking and avoidance, as their coping methods.