The purpose of this paper is to report the application of Peplau's theo ry to helping a schizophrenic patient deal with drug noncompliance. It was found that the main reasons for noncompliance were poor insight and lack of illness and drug-related knowledge. Based on Peplau's theory of establishing a therapeutic relationship, giving guidance in medication and monitoring the effects of medication in order to improve drug compliance, the most important role of the nurse is as assessor and educator. Nurse and patient were able to learn to achieve the common goal of drug compliance through ther interactive human relationship.