Electronic mail has been playing a more and more important role in human communication activities. This paper is aimed at exploring critical issues while using this new media. The author firstly presents the definition of E-mail etiquette, then introduces some common rules of sending and receiving E-mails. Skillfully utilizing smilies, intensifiers,and abbreviations are recommended in the cyperspace environment. The paper is wrapped up by a abbreviations University campus case to explain how E-mail etiquette works in real life.