The main purpose of this descriptive correlational study was to explore the relationships among demographic variables, characteristics of disease, hardiness personality, and life adjustment in patients with spinal cord injury (SCI). A convient sample of eighty patients, experienced SCI at least two months already, was interviewed at a medical center, National Association of SCI, or their home. Several self - designed instruments, such as: Life Adjustment Scale (LAS); Personal Hardiness Scale (PHS); and demographic and disease - related variables, were used for data collection. In the dimension of physical adjustment in LAS, bladder and bowel incontinence were the most severe problems related to self - care and somatic complaints. Meanwhile, the ability to perform these affairs, such as: getting up and down stairs; walking on flat floor; and standing; needed extreme assistance. In the psychosocial adjustment dimension of LAS, the sample reported best adjustment of personal health and relationship with their family and the worst adjustment in the employment status. In addition, PHS was positively correlated with the psychological adjustment of the LAS. Specifically, the control and involvement (投入 ) dimensions of the PHS were positively correlated with the psychological adjustment of LAS. The control, challenge, and whole dimension of the PHS were positively correlated with the social - environmental adjustment of LAS. The involvement dimension of the PHS was positively correlated with the emplovment status of LAS. The control dimension of the PHS were positively correlated with the psychosocial adjustment of LAS. Nevertheless, several variables were positively correlated with the LAS, such as: age, employment status, duration of return work, marital status educational status, duration of illness, and degree of paralysis. These samples were severely handicapped. They have to face the long process of adjustment. Therefore, nurses should enhance the self - care and mobility ability of these patients. Then, the goal of adaptation of stress of disease and promote their quality of life can be achieved.