肺癌之流行病學特徵、危險因子及防治策略__臺灣人文及社會科學引文索引資料庫

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題名：	肺癌之流行病學特徵、危險因子及防治策略
書刊名：	中華公共衛生雜誌
作者：	廖國盟／陳建仁
作者(外文)：	Liaw, Gao-meng／Chen, Chien-jen
出版日期：	1997
卷期：	16:5
頁次：	頁375-395
主題關鍵詞：	流行病學；危險因子；肺癌；Epidemiology；Risk factors；Lung cancer
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:1 點閱:62

　　　　　本文回顧綜述近年來肺癌的流行病學特徵及危險因子之文獻。臺台灣地區的肺癌發生率在三十年來增加近八倍，是增加最快的癌症之一。按其增加的速率估計，在二十一世紀初可能就會成為國人最重要的癌症。在基礎醫學、臨床醫學及流行病學上，都有一致的證據顯示吸菸走肺癌最重要的因子，二手菸暴露也被證實為肺癌之危險因子。職業及居家之氧氣暴露及其他化學致癌物如：石綿、砷、多環芳香煙的暴寒，以及遺傳之易罹癌性、營養攝取不足也走重要的致病因子。吸菸率偏低的華人女性卻有偏高的肺癌發生率，其重要危險因子有待探討，烹調油煙、二手菸、遺傳之易罹癌性、性荷爾蒙都是值得鑽研的主題。初級預防走防治肺癌的根本之道，低焦油香菸不能根本解決問題，戒菸才是最為重要。化學預防可能會降低戒菸者之肺癌發生卒，但目前所得到的結果卻仍有爭議。早期發現癌症也走防治肺癌的新方向，利用痰細胞學檢驗輔以單株抗體進行免疫細胞化學分析法，是一個有潛力的篩檢工具。p53 基因的突變，有可能成為早期診斷的指標。

以文找文

　　　　　This article reviews the researches on the epidemiologic characteristics and risk factors of primary lung cancer in the recent decade. Primary lung cancer incidence and mortality have been increasing rapidly during past thirty years in Taiwan. Consistent evidences in basic researches, clinical observations, and epidemiological studies have shown that cigarette smoking is the most important risk factor for lung cancer. Environmental tobacco smoking has also been documented as lung cancer risk factor. Occupational and domestic radon exposure and other occupational hazards, including asbestos, arsenic, and polycyclic aryl hydrocarbon have also been reported to be associated with the development of lung cancer. The association of genetic susceptibility and micro-nutrients with lung cancer needs further assessment. The low prevalence of cigarette smoking and relatively high incidence rate of primary lung adenocarcinoma among Chinese and Taiwanese women suggests the existence of some important risk factors to be elucid. The associations with lung cancer risk for cooking oil fumes, history of lung diseases, and reproductive factors have been intensively investigated. Among the strategies toward the prevention of lung cancer, smoking cessation is the most important. Chemoprevention may reduce the risk of lung cancer among ex-smokers, but there remains debates about the protective effect of b-carotene and retinoids. Early detection is an alter- native to reduce lung cancer mortality. Immuno-cytochemical analysis of sputum using monoclonal antibody may be a potential tool for the screening of lung cancer. Polymerase chain reaction aiming to search for an activated ras gene or p53 mutation from exfoliated bronchial epithelial cells is another promising technique for early detection of lung cancer.

以文找文

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120.	Chiang, M. H.、Liaw, K. F.、Horng, S. F.、Hsueh, Y. M.、Chiou, H. Y.(1995)。Incidence of Internal Cancers and Ingested Inorganic Arsenic: A Seven-Year Follow-up Study in Taiwan。Cancer Research，55，1296-1300。

會議論文
1.	Bogovski, P.、Gilson, J. G.、Timbrell, V.(1972)。Biological effects of asbestos: Proceedings of a working conference held at the IARC。IARC Scientific Publication。Lyon：Scientific Publication。

學位論文
1.	Lee, L. T.(1993)。Epidemiologic characteristics of pulmonary tuberculosis and association between pulmonary tuberculosis and lung cancer in Taiwan(博士論文)。National Taiwan University。
2.	賴大年(1994)。臺灣地區十二鄉鎮區居民吸菸對各種死因之世代追蹤研究(碩士論文)。國立臺灣大學。延伸查詢

圖書
1.	Parkin, D. M.、Muir, C. S.、Whelan, S. L.(1992)。Cancer incidence in five continents。Lyon：International Agency for Research on Cancer。
2.	Higginson, J.、Muir, C. S.、Muñoz, N.(1992)。Human cancer: epidemiology and environmental causes。Cambridge：Cambridge University Press。
3.	International Agency for Research on Cancer(1986)。IARC monographs on the evaluation of carcinogenic risks to humans: Tobacco smoking。Lyon：International Agency for Research on Cancer。
4.	US Public Health Service(1982)。The health consequences of smoking: Cancer. A Report of the Surgeon General。Rockville, Maryland：US DHHS, Public Health Service, Office on Smoking and Health。
5.	National Research Council (U.S.)、Committee on Passive Smoking(1986)。Environmental tobacco smoke: measuring exposures and assessing health effects。Washington：National Academy Press。
6.	International Agency for Research on Cancer(1988)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Manmade Mineral Fibers and Radon。Lyon：International Agency for Research on Cancer。
7.	International Agency for Research on cancer(1987)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Overall evaluations of Carcinogenicity: an updating of IARC Monographs。Lyon：International Agency for Research on Cancer。
8.	International Agency for Research on Cancer(1988)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Polycyclic aromatic hydrocarbon。Lyon：International Agency for Research on Uanccr。
9.	International Agency for Research on Cancer(1995)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Wood dust and formaldehyde。Lyon：International Agency for Research on Cancer。
10.	International Agency for Research on Cancer(1987)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Silica and some silicates。Lyon：International Agency for Research on Cancer。
11.	Doll, R.(1982)。Cadmium in the human environment。Lyon：International Agency for Research on Cancer。
12.	International Agency for Research on Cancer(1990)。IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Chromium: nickel and molding。Lyon：International Agency for Research on Cancer。
13.	WolBach, S. B.(1954)。Effects of vitamin A deficiency and hyper-vitaminosis A in animals。New York：Academic Press。
14.	NRC Committee on the Biological Effects of Ionizing Radiation(1988)。Health risks of radon and other internally deposited alpha-emitters。Washington：National Academy Press。
15.	UNSCEAR(1988)。Sources, effects and risks of ionizing radiation。New York：United Nations。
16.	US Public Health Service(1992)。The health consequences of smoking: cancer. A report of the Surgeon General。Rockville, Maryland：US DHHS, Public Health Service。
17.	US Public Health Service(1990)。The health benefits of smoking cessation: A report of the Surgeon General。Rockville, Maryland：US DHHS, Public Health Service。
18.	US Public Health Service(1989)。Reducing the health consequences of smoking: A report of the Surgeon General。Rockville, Maryland：US DHHS, Public Health Service, Office on Smoking and Health。
19.	US Public Health Service(1979)。Smoking and health: A report of the Surgeon General。Rockville, Maryland：US DHHS, Public Health Service, Office on Smoking and Health。

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