This paper chooses 14 Digital Humanities Centers in American’s colleges with great reputation,and investigates the name, organizational affiliation, personnel composition, projects and the library-related information. Based on the data,this paper analyzes the mode of the Digital Humanities Center. Digital Humanities research in China is still at its early stage. And it is symbiosis between library and the Digital Humanities. The library in China should improve the environment of Open Access, strengthen the personnel training, initiate a Digital Humanities project,enhance the academic exchange and projects cooperation, and promote the Digital Humanities developments.