親代孕前成癮藥物暴露對子代行為的影響及其表觀遺傳機制_

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題名：	親代孕前成癮藥物暴露對子代行為的影響及其表觀遺傳機制
書刊名：	心理科學進展
作者：	張克／段穎／杜秀敏
出版日期：	2017
卷期：	2017(10)
頁次：	1791-1798
主題關鍵詞：	成癮藥物；孕前；表觀遺傳；生殖細胞；Addictive drug；Preconception；Epigenetic；Germ cell
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:9

孕前成癮藥物暴露不僅危害使用者的身體健康,而且會對子代的生理行為造成影響,近年來研究發現表觀遺傳機制在其中發揮重要作用。孕前成癮藥物暴露會對子代的成癮易感性和焦慮樣行為造成影響,引起子代的抑郁樣行為和認知受損。這些現象可能是成癮藥物通過引起親代生殖細胞內表觀遺傳修飾變化所致,其中包括印記基因、神經遞質系統、BDNF三個方面的表觀遺傳修飾變化。此外,未來除了加強以上三個方面基因的研究,也需要增加其他方面基因的研究,以及尋找能預測子代異常行為的表觀遺傳生物標志物。

以文找文

Parental preconception exposure to addictive drugs influences not only parents themselves,but also their offsprings’ physiological function and behavior.In recent years,research shows that the epigenetic alterations play a vital role in abnormal behavior.Parental preconception exposure to addictive drugs influences the offsprings’ susceptibility to drug addiction and anxiety-like behavior,induces offsprings’ depression-like behavior and cognitive impairment.Epigenetic alterations in germ cells induced by preconception exposure to addictive drugs contribute to the onset of offsprings’ abnormal behavior through the changes of imprinted gene,BDNF,and neurotransmitter system.Future studies,besides strengthening the above three aspects research,should pay attention to other aspects of genes and to try to find the epigenetic biomarker in germ cells for the prediction of the offsprings’ abnormal behavior.

以文找文

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