【Purpose/significance】Big data has great potential, but it also poses great risks to the information security of individuals and enterprises. It is of great significance to study information security issues in the era of big data.【Method/process】By analyzing the main influencing factors of information security in the era of big data and the problems of information security in the era of big data, combined with the new characteristics of information security in the era of big data, this paper proposes a strategy to ensure information security in the era of big data.【Result/conclusion】The results have practical guiding significance for individuals, enterprises and the state to establish and improve information security management system at all levels in the era of big data.