There are great numbers of Taiwanese entrepreneurs migrating to Mainland China currently. Characteristics of their working and living adjustment are quite different from those of other international migrants. It is a special pattern of migration adjustment. The present study attempts to investigate the social interaction problems of these Taiwanese emigrating entrepreneurs with people in Mainland China from demographic-sociological point of view. The author hypothesizes that these migrants confront three aspects of social interaction problems in their working and living adjustment process in Mainland China. These three aspects of social interaction are (1) the interaction with government officers; (2) the interaction with local employees; (3) the interaction with local people. More detailed problems in these three aspects of social interaction have been examined and tested. Available data for this study are collected through interviewing Taiwanese entrepreneurs in Mainland China, reviewing related references and doing field observation.