The focus of this paper is to deal with the retrospect and prospect of Southeast Asian Studies in Mainland China. Also, this paper attempts to find out what the contexts and structures of China’s Southeast Asian Studies are. Concerned with the methodological aspects in this paper, four issues will be involved and solved for the following discussion. First is to discuss how the development of China’s Southeast Asian Studies is influenced by the rise of her economy and politics. Also, it is interested to examine how the development of China’s Southeast Asian Studies is shaped by the improvement of economic and diplomatic relations between China and ASEAN. Second is to summarize the development direction, issues, and tendency of Southeast Asian Studies as a whole in China, Third is to entirely analyze the research resources, structures, and institutes of China’s Southeast Asian Studies. The last is to present those what are strengths and weakness of the whole research development on China’s Southeast Asian Studies.