Many movies, especially animation films, are actually originated from popular comics. The development history of Comics, Animation and Movie has inseparable relations and their performance forms influence each other. This paper uses qualitative approaches to discuss the feasibility of applying the form of comic panel to the animation. It studies the development history of animation and comics, the visual element of comics, the montage and time conception of movie, and analyzes the connection way of comic panel, the application to the animation effect and limitation, and even the animation creation. The conclusion of this study discovers that applying comics panel to animation not only can employ the uniquely connective attribute of panel to animation and represent an alternative style, but also use the visual attraction of the image guiding viewers to watch the sequence of multi panels. Since comics and animation are two different art forms of media, when the panel of comic applying to animation, proper organizing of the panel's quantity, content, size and the retention time is needed to make sure the viewers recognize these attributes completely.