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題名:飢餓素與運動
書刊名:運動生理暨體能學報
作者:王鶴森 引用關係林正常 引用關係
作者(外文):Wang, Ho-sengLin, Jung-charng
出版日期:2006
卷期:5
頁次:頁1-10
主題關鍵詞:運動飢餓素生長激素ExerciseGhrelinGrowth hormone
原始連結:連回原系統網址new window
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  • 被引用次數被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:1
  • 共同引用共同引用:1
  • 點閱點閱:38
飢餓素(ghrelin)是一種由28個胺基酸所組成的多胜肽激素,其可透過生長激素分泌接受器(growth hormone secretagogue receptor, GHSR),而具有強力刺激生長激素分泌的作用。此外,越來越多的研究也顯示飢餓素在進食行為及能量的恆定方面亦扮演重要的角色。雖然飢餓素是在下視丘被發現的,但是循環中大多數的飢餓素卻是由胃部所分泌。目前已有許多因子被證實可以影響飢餓素,例如:進食、睡眠、日夜節律、體重、生殖激素,以及還可能包括運動。運動和飢餓素一樣都可以刺激生長激素的分泌,不過研究指出運動中飢餓素濃度並未隨著生長激素上升,顯示運動所誘發的生長激素增加並非經由飢餓素所引起的。另外,長期運動所引起的體重下降,已經被觀察到同時也伴隨有空腹時飢餓素濃度增加的現象,不過,在單次運動對飢餓素濃度影響的研究結果則不一致,有些認為沒有改變,有些則是在運動後顯著下降,這些矛盾仍需要未來更多的研究加以釐清。
Ghrelin, a 28-amino-acid peptide, is the endogenous ligand for the growth hormone secretagogue receptor (GHSR) and potently stimulates growth hormone (GH) release. In addition, there is increasing evidences to show that ghrelin acts as a key role in regulating food intake and energy homeostasis. Although the ghrelin is found in the hypothalamus, most circulating ghrelin is secreted from the stomach. Ghrelin would be affected by many factors: for instance, food intake, sleep, body weight, diurnal rhythm, reproduction hormone and perhaps exercise. Exercise also is a well-known stimulator of GH secretion as ghrelin, but is not observed with significant increase in plasma ghrelin levels. It means that ghrelin is not the stimulator in the exercise-induced stimulation of GH release. Besides, weight loss by long-term exercise is associated with an increase in fasting plasma ghrelin levels. In contrast, previous research has given contradictory results, showing either an unchanged or decreased ghrelin levels after an acute exercise. Further studies are needed to fully elucidate this contradiction.
期刊論文
1.Broglio, F.、Gottero, C.、Arvat, E.、Ghigo, E.(2003)。Endocrine and non-endocrine actions of ghrelin。Hormone Research,59(3),109-117。  new window
2.Chan, J. L.、Bullen, J.、Lee, J. H.、Yiannakouris, N.、Mantzoros, C. S.(2004)。Ghrelin levels are not regulated by recombinant leptin administration and or three days of fasting in healthy subjects。The Journal of Clinical Endocrinology and Metabolism,89(1),335-343。  new window
3.Cummings, D. E.、Purnell, J. Q.、Frayo, R. S.、Schmidova, K.、Wisse, B. E.、Weigle, D. S.(2001)。A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans。Diabetes,50(8),1714-1719。  new window
4.Cummings, D. E.、Weigle, D. S.、Frayo, R. S.、Breen, P. A.、Ma, M. K.、Dellinger, E. P.(2002)。Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery。The New England Journal of Medicine,346(21),1623-1630。  new window
5.Date, Y.、Kojima, M.、Hosoda, H.、Sawaguchi, A.、Mondal, M. S.、Suganuma, T.(2000)。Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans。Endocrinology,141(11),4255-4261。  new window
6.De-Souza, M. J.、Leidy, H.、O'Donnell, E.、Lasley, B.、Williams, N. I.(2004)。Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones。The Journal of Clinical Endocrinology and Metabolism,89(7),3536-3542。  new window
7.Dzaja, A.、Dalai, M. A.、Himmierich, H.、Uhr, M.、Pollmächer, T.、Schuld, A.(2004)。Sleep enhances nocturnal plasma ghrelin levels in healthy subjects。American Journal of Physiology: Endocrinology and Metabolism,286(6),E963-E967。  new window
8.Fernandez-Fernandez, R.、Martini, A. C.、Navarro, V. M.、Castellano, J. M.、Dieguez, C.、Aguilar, E.(2006)。Novel signals for the integration of energy balance and reproduction。Molecular and Cellular Endocrinology。  new window
9.Fernandez-Fernandez, R.、Tena-Sempere, M.、Aguilar, E.、Pinilla, L.(2005)。Ghrelin effects on gonadotropin secretion in male and female rats。Neuroscience Letters,362(2),103-107。  new window
10.Foster-Schubert, K. E.、McTieman, A.、Frayot, R. S.、Schwartz, R. S.、Rajan, K. B.、Yasui, Y.(2005)。Human plasma ghrelin levels increases during a one-year exercise program。The Journal of Clinical Endocrinology and Metabolism,90(2),820-825。  new window
11.Greenman, Y.、Golani, N.、Gilad, S.、Yaron, M.、Limor, R.、Stern, N.(2004)。Ghrelin secretion is modulated in a nutrient- and gender-specific manner。Clinical Endocrinology,60(3),382-388。  new window
12.Huda, M. S. B.、Wilding, J. P. H.、Pinkney, J. H.(2006)。Gut peptides and the regulation of appetite。Obesity Reviews,7,163-182。  new window
13.Iglesias, M. J.、Pineiro, R.、Blanco, M.、Gallego, R.、Dieguez, C.、Gualillo, O.(2004)。Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes。Cardiovascular Research,62(3),442-443。  new window
14.Inui, A.、Asakawa, A.、Bowers, C. Y.、Mantovani, G.、Laviano, A.、Meguid, M. M.(2004)。Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ。The FASEB Journal,18,439-456。  new window
15.Kellokoski, E.、Poykko, S. M.、Karjalainen, A. H.、Ukkola, O.、Heikkinen, J.、Kesaniemi, Y. A.(2005)。Estrogen replacement therapy increases plasma ghrelin levels。The Journal of Clinical Endocrinology and Metabolism,90(5),2954-2963。  new window
16.Kojima, M.、Hosoda, H.、Date, Y.、Nakazato, M.、Matsuo, H.、Kangawa, K.(1999)。Ghrelin is a growth-hormone-releasing acylated peptide from stomach。Nature,402(6762),656-660。  new window
17.Kraemer, R. R.、Durand, R. J.、Acevedo, E. O.、Johnson, L. G.、Kraemer, G. R.、Hebert, E. P.(2004)。Rigorous running increases growth hormone and insulin-like growth factor-1 without altering ghrelin。Experimental Biology and Medicine,229,240-246。  new window
18.Kraemer, R. R.、Durand, R. J.、Hollander, D. B.、Tryniecki, J. L.、Hebert, E. P.、Castracane, V. D.(2004)。Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions。Endocrine,24(1),93-98。  new window
19.Monteleone, P.、Bencivenga, R.、Longobardi, N.、Serritella, C.、Maj, M.(2003)。Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women。The Journal of Clinical Endocrinology & Metabolism,88(11),5510-5514。  new window
20.Schmidt, A.、Maier, C.、Schaller, G.、Nowotny, P.、Bayerle-Eder, M.、Buranyi, B.(2004)。Acute exercise has no effect on ghrelin plasma concentrations。Hormone and Metabolic Research,36(3),174-177。  new window
21.Schwartz, M. W.、Woods, S. C.、Porte, Jr. D.、Seeley, R. J.、Baskin, D. G.(2000)。Central nervous system control of food intake。Nature,404,661-671。  new window
22.Soriano-Guillen, L.、Barrios, V.、Lechuga-Sancho, A.、Chowen, J. A.、Argente, J.(2004)。Response of circulating ghrelin levels to insulin threapy in children with newly diagnosed type I diabetes mellitus。Pediatric Research,55(5),830-835。  new window
23.Taheri, S.、Lin, L.、Austin, D.、Young, T.、Mignot, E.(2004)。Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index。PLoS Medicine,1(3),210-217。  new window
24.Tolle, V.、Kadem, M.、Bluet-Pajot, M. T.、Frere, D.、Foulon, C.、Bossu, C.(2003)。Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women。The Journal of Clinical Endocrinology & Metabolism,88,109-116。  new window
25.Tschopt, M.、Smiley, D. L.、Heiman, M. L.(2000)。Ghrelin induces adiposity in rodents。Nature,407,908-913。  new window
26.Tschop, M.、Weyer, C.、Tataranni, P. A.、Devanarayan, V.、Ravussin, E.、Heiman, M. L.(2001)。Circulating ghrelin levels are decreased in human obesity。Diabetes,50,707-709。  new window
27.Weikel, J. C.、Wichniak, A.、Ising, M.、Friess, E.、Held, K.、Brunner, H.(2003)。Ghrelin promotes slow-wave sleep in humans。American Journal of Physiology: Endocrinology and Metabolism,284(2),E407-E415。  new window
28.Wuorinen, E. C.、Lin, P. J.、Burant, C.、Borer, K. T.(2004)。Exercise-induced ghrelin secretion is associated with increased lipolysis。Medicine and Science in Sports and Exercise,36(5),S140。  new window
29.Zoladz, J. A.、Konturek, S. J.、Duda, K.、Majerczak, J.、Sliwowski, Z.、Grandys, M.(2005)。Effect of moderate incremental exercise, performed in fed and fasted state on cardio-respiratory variables and leptin and ghrelin concentrations in young healthy men。Journal of Physiology and Pharmacology,56(1),63-85。  new window
30.Leidy, H. J.、Gardner, J. K.、Frye, B. R.、Snook, M. L.、Schuchert, M. K.、Richard, E. L.(2004)。Circulating ghrelin is sensitive to change in body weight during a diet and exercise program in normal-weight young women。The Journal of Clinical Endocrinology and Metabolism,89(6),2659-2664。  new window
學位論文
1.王鶴森(2006)。濾泡與黃體期間從事中等強度運動對血漿飢餓素及瘦體素濃度的影響(博士論文)。國立臺灣師範大學。new window  延伸查詢new window
 
 
 
 
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