This study explores key challenges facing industries in Kaohsiung City by systematically analyzing industrial structures in the city. Subsequently, this paper proposes promotion strategies for future developments of 10 industries in Kaohsiung City by conducting a SWOT analysis approach. The research proposed to package high-value steel, digital content, green energy, harbor logistics, petrochemical chemistry industry environment protection and high value-added, yacht cluster and specific zone, business headquarter, biomedical material, tourism & travel and advanced agriculture as the 10 major industries of Kaohsiung City, and then develop an integral strategies to promote Kaohsiung’s industries effectively.