Since the inauguration of the Obama administration in 2008, the US has introduced several important military, political and national security policy documents. Relevant documents clearly point out that the administration places high regard towards proliferation of nuclear weapons and weapons of mass destruction while also sketching a strategic blueprint of weapon allocation. This article points out that the future strategy of the US government would revolve around the three core issues of national defense adjustment, nuclear anti-proliferation and continued attention on major nuclear states. In terms of national defense, even though the US would continue to cooperate with Russia in nuclear reduction, performance and power of nuclear delivery vehicle and non-nuclear weapons would be actively upgraded in order to maintain deterrence capability. Regarding foreign policy, Iran, North Korea, China and Russia are the main targets of US nuclear strategy. Despite the fact that active research by Iran and North Korea has yet to constitute a threat on the US homeland, they have grown into a regional security threat. The US may continue to seek diplomacy to mitigate the situation. On the other hand, China and Russia own capabilities powerful enough to threaten the US homeland. The US will continue to promote dialogue between the powers in search of cooperation regarding treatment of nuclear issues while maintaining its guard against China and Russia. Finally, the US would actively monitor the development of nuclear facilities through international cooperation, technological advancement and facility control, in preventing weapon proliferation.